The Virtual USB Bus driver ( vusbbus.sys ) is test-signed. Windows blocks it unless test signing is on.
If disabling Core Isolation doesn't work, corrupted registry "filters" might be blocking the driver. Press , type regedit , and hit Enter. mastercam x72022 virtual usb bus error 39 fix
Open regedit and delete these keys :
If the error persists, proceed step-by-step. The Virtual USB Bus driver ( vusbbus